Host sirtuin 2 as an immunotherapeutic target against tuberculosis

Host sirtuin 2 as an immunotherapeutic target against tuberculosis

Mycobacterium tuberculosis (Mtb) employs plethora of mechanisms to hijack the host defence machinery for its successful survival, proliferation and persistence. Here, we show that Mtb upregulates one of the key epigenetic modulators, NAD+ dependent histone deacetylase Sirtuin 2 (SIRT2), which upon i...

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Bibliographic Details
Main Authors: Ashima Bhaskar, Santosh Kumar, Mehak Zahoor Khan, Amit Singh, Ved Prakash Dwivedi, Vinay Kumar Nandicoori
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-07-01
Series:eLife
Subjects:
mycobacterium tuberculosis
AGK2
histones
immunotherapy
SIRT2
epigenetics
Online Access:https://elifesciences.org/articles/55415

Internet

https://elifesciences.org/articles/55415

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