PI 3-Kinase and the Histone Methyl-Transferase KMT2D Collaborate to Induce Arp2/3-Dependent Migration of Mammary Epithelial Cells

PI 3-Kinase and the Histone Methyl-Transferase KMT2D Collaborate to Induce Arp2/3-Dependent Migration of Mammary Epithelial Cells

Breast cancer develops upon sequential acquisition of driver mutations in mammary epithelial cells; however, how these mutations collaborate to transform normal cells remains unclear in most cases. We aimed to reconstitute this process in a particular case. To this end, we combined the activated for...

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Bibliographic Details
Main Authors: Karina D. Rysenkova, Julia Gaboriaud, Artem I. Fokin, Raphaëlle Toubiana, Alexandre Bense, Camil Mirdass, Mélissa Jin, Minh Chau N. Ho, Elizabeth Glading, Sophie Vacher, Laura Courtois, Ivan Bièche, Alexis M. Gautreau
Format: Article
Language:English
Published: MDPI AG 2024-05-01
Series:Cells
Subjects:
KMT2D
MLL2
MLL4
PIK3CA
Arp2/3
Online Access:https://www.mdpi.com/2073-4409/13/10/876

Internet

https://www.mdpi.com/2073-4409/13/10/876

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