Melatonin Decreases Pulmonary Vascular Remodeling and Oxygen Sensitivity in Pulmonary Hypertensive Newborn Lambs

Melatonin Decreases Pulmonary Vascular Remodeling and Oxygen Sensitivity in Pulmonary Hypertensive Newborn Lambs

Background: Chronic hypoxia and oxidative stress during gestation lead to pulmonary hypertension of the neonate (PHN), a condition characterized by abnormal pulmonary arterial reactivity and remodeling. Melatonin has strong antioxidant properties and improves pulmonary vascular function. Here, we ai...

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Bibliographic Details
Main Authors: Cristian R. Astorga, Alejandro González-Candia, Alejandro A. Candia, Esteban G. Figueroa, Daniel Cañas, Germán Ebensperger, Roberto V. Reyes, Aníbal J. Llanos, Emilio A. Herrera
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Physiology
Subjects:
neonatal pulmonary hypertension
vascular remodeling
hypoxic pulmonary vasoconstriction
chronic hypoxia
oxidative stress
melatonin
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2018.00185/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2018.00185/full

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