Regulators of the proteasome pathway, Uch37 and Rpn13, play distinct roles in mouse development.

Regulators of the proteasome pathway, Uch37 and Rpn13, play distinct roles in mouse development.

Rpn13 is a novel mammalian proteasomal receptor that has recently been identified as an amplification target in ovarian cancer. It can interact with ubiquitin and activate the deubiquitinating enzyme Uch37 at the 26S proteasome. Since neither Rpn13 nor Uch37 is an integral proteasomal subunit, we ex...

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Bibliographic Details
Main Authors: Amin Al-Shami, Kanchan G Jhaver, Peter Vogel, Carrie Wilkins, Juliane Humphries, John J Davis, Nianhua Xu, David G Potter, Brenda Gerhardt, Robert Mullinax, Cynthia R Shirley, Stephen J Anderson, Tamas Oravecz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2965108?pdf=render

Internet

http://europepmc.org/articles/PMC2965108?pdf=render

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