Structural insights into anion selectivity and activation mechanism of LRRC8 volume-regulated anion channels

Structural insights into anion selectivity and activation mechanism of LRRC8 volume-regulated anion channels

Summary: Volume-regulated anion channels (VRACs) are hexamers of LRRC8 proteins that are crucial for cell volume regulation. N termini (NTs) of the obligatory LRRC8A subunit modulate VRACs activation and ion selectivity, but the underlying mechanisms remain poorly understood. Here, we report a 2.8-Å...

Full description

Bibliographic Details
Main Authors: Heng Liu, Maya M. Polovitskaya, Linlin Yang, Meiling Li, Hongyue Li, Zhen Han, Jianguo Wu, Qiansen Zhang, Thomas J. Jentsch, Jun Liao
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Cell Reports
Subjects:
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723009373

Internet

http://www.sciencedirect.com/science/article/pii/S2211124723009373

Similar Items