Neoadjuvant chemotherapy is associated with suppression of the B cell-centered immune landscape in pancreatic ductal adenocarcinoma

Neoadjuvant chemotherapy is associated with suppression of the B cell-centered immune landscape in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is typically diagnosed at advanced stages and associated with early distant metastasis and poor survival. Besides clinical factors, the tumor microenvironment (TME) emerged as a crucial determinant of patient survival and therapy response in many tumors, inclu...

Full description

Bibliographic Details
Main Authors: Luise Rupp, Ina Dietsche, Maximilian Kießler, Ulrich Sommer, Alexander Muckenhuber, Katja Steiger, Casper W. F. van Eijck, Leonard Richter, Rouzanna Istvanffy, Carsten Jäger, Helmut Friess, Casper H. J. van Eijck, Ihsan Ekin Demir, Carmen Mota Reyes, Marc Schmitz
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Immunology
Subjects:
pancreatic ductal adenocarcinoma
tumor immune contexture
B cells
plasma cells
neoadjuvant chemotherapy
tertiary lymphoid structures
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1378190/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1378190/full

Similar Items