A New Oxadiazole-Based Topsentin Derivative Modulates Cyclin-Dependent Kinase 1 Expression and Exerts Cytotoxic Effects on Pancreatic Cancer Cells

A New Oxadiazole-Based Topsentin Derivative Modulates Cyclin-Dependent Kinase 1 Expression and Exerts Cytotoxic Effects on Pancreatic Cancer Cells

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal form of cancer characterized by drug resistance, urging new therapeutic strategies. In recent years, protein kinases have emerged as promising pharmacological targets for the treatment of several solid and hematological tumors. Interestingly...

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Bibliographic Details
Main Authors: Camilla Pecoraro, Barbara Parrino, Stella Cascioferro, Adrian Puerta, Amir Avan, Godefridus J. Peters, Patrizia Diana, Elisa Giovannetti, Daniela Carbone
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Molecules
Subjects:
1,2,4-oxadiazole
marine alkaloids
topsentin
CDK1 inhibitor
pancreatic cancer
PDAC
Online Access:https://www.mdpi.com/1420-3049/27/1/19

Internet

https://www.mdpi.com/1420-3049/27/1/19

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