Homocysteine accelerates hepatocyte autophagy by upregulating TFEB via DNMT3b-mediated DNA hypomethylation

Homocysteine accelerates hepatocyte autophagy by upregulating TFEB via DNMT3b-mediated DNA hypomethylation

Autophagy plays a critical role in the physiology and pathophysiology of hepatocytes. High level of homocysteine (Hcy) promotes autophagy in hepatocytes, but the underlying mechanism is still unknown. Here, we investigate the relationship between Hcy-induced autophagy level and the expression of nuc...

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Bibliographic Details
Main Authors: Yang Anning, Zeng Wen, Zhang Hongwen, Hao Yinju, Wang Qingqing, Sun Yue, Quan Shangkun, Ding Ning, Yang Xiaoling, Sun Jianmin, Zhang Huiping, Liu Bin, Jiao Yun, Wu Kai, Jiang Yideng
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2023-04-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
homocysteine
TFEB
autophagy
DNA methylation
DNA methyltransferase 3b
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2023060

Internet

https://www.sciengine.com/doi/10.3724/abbs.2023060

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