SMRT and NCoR1 fine-tune inflammatory versus tolerogenic balance in dendritic cells by differentially regulating STAT3 signaling

SMRT and NCoR1 fine-tune inflammatory versus tolerogenic balance in dendritic cells by differentially regulating STAT3 signaling

Dendritic cell (DC) fine-tunes inflammatory versus tolerogenic responses to protect from immune-pathology. However, the role of co-regulators in maintaining this balance is unexplored. NCoR1-mediated repression of DC immune-tolerance has been recently reported. Here we found that depletion of NCoR1...

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Bibliographic Details
Main Authors: Atimukta Jha, Abdul Ahad, Gyan Prakash Mishra, Kaushik Sen, Shuchi Smita, Aliva Prity Minz, Viplov Kumar Biswas, Archana Tripathy, Shantibhushan Senapati, Bhawna Gupta, Hans Acha-Orbea, Sunil Kumar Raghav
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
SMRT and NCoR1
dendritic cells
Th1/Th17 T-cell response
mTOR-STAT3-IL10 signaling
Nr4a1
comparative genomic and transcriptomic (RNA-seq and ChIP-seq)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.910705/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.910705/full

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