How do lifestyle factors modify the association between genetic predisposition and obesity-related phenotypes? A 4-way decomposition analysis using UK Biobank

How do lifestyle factors modify the association between genetic predisposition and obesity-related phenotypes? A 4-way decomposition analysis using UK Biobank

Abstract Background Obesity and central obesity are multifactorial conditions with genetic and non-genetic (lifestyle and environmental) contributions. There is incomplete understanding of whether lifestyle modifies the translation from respective genetic risks into phenotypic obesity and central ob...

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Bibliographic Details
Main Authors: Mengrong Zhang, Joey Ward, Rona J. Strawbridge, Carlos Celis-Morales, Jill P. Pell, Donald M. Lyall, Frederick K. Ho
Format: Article
Language:English
Published: BMC 2024-06-01
Series:BMC Medicine
Subjects:
Obesity
Central obesity
BMI-PRS
WHR-PRS
Total lifestyle factors
Online Access:https://doi.org/10.1186/s12916-024-03436-6

Internet

https://doi.org/10.1186/s12916-024-03436-6

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