Combined α-methylacyl-CoA racemase inhibition and docetaxel treatment reduce cell proliferation and decrease expression of heat shock protein 27 in androgen receptor-variant-7–positive prostate cancer cells

Combined α-methylacyl-CoA racemase inhibition and docetaxel treatment reduce cell proliferation and decrease expression of heat shock protein 27 in androgen receptor-variant-7–positive prostate cancer cells

Background: Disease progression in castrate-resistant prostate cancer (PCa) is most commonly driven by the reactivation of androgen receptor (AR) signaling and involves AR splice variants including ARV7. Materials and methods: We used the ARV7-positive PCa cell line, 22Rv1, to study the relationship...

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Bibliographic Details
Main Authors: Atsuhiko Yoshizawa, Kiyoshi Takahara, Masanobu Saruta, Kenji Zennami, Takuhisa Nukaya, Kosuke Fukaya, Manabu Ichino, Naohiko Fukami, Atsuko Niimi, Hitomi Sasaki, Mamoru Kusaka, Motoshi Suzuki, Makoto Sumitomo, Ryoichi Shiroki
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Prostate International
Subjects:
AMACR
ARV7
Docetaxel
HSP27
Prostate cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2287888220300465

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http://www.sciencedirect.com/science/article/pii/S2287888220300465

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