P2Y6 and P2X7 Receptor Antagonism Exerts Neuroprotective/ Neuroregenerative Effects in an Animal Model of Parkinson’s Disease

P2Y6 and P2X7 Receptor Antagonism Exerts Neuroprotective/ Neuroregenerative Effects in an Animal Model of Parkinson’s Disease

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by decreased dopamine bioavailability in the substantia nigra and the striatum. Taking into account that adenosine-5’-triphosphate (ATP) and its metabolites are intensely released in the 6-hydroxydopamine (6-OHDA) animal model of...

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Bibliographic Details
Main Authors: Ágatha Oliveira-Giacomelli, Carolina M. Albino, Hellio Danny Nóbrega de Souza, Juliana Corrêa-Velloso, Ana Paula de Jesus Santos, Juliana Baranova, Henning Ulrich
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
purinergic receptors
Brilliant Blue G
P2X7 receptor
MRS2578
P2Y6 receptor
Parkinson’s disease
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00476/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00476/full

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