Genome-wide identification of genetic determinants for the cytotoxicity of perifosine

Genome-wide identification of genetic determinants for the cytotoxicity of perifosine

<p>Abstract</p> <p>Perifosine belongs to the class of alkylphospholipid analogues, which act primarily at the cell membrane, thereby targeting signal transduction pathways. In phase I/II clinical trials, perifosine has induced tumour regression and caused disease stabilisation in a...

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Bibliographic Details
Main Authors: Zhang Wei, Liu Wanqing, Poradosu Enrique, Ratain Mark J
Format: Article
Language:English
Published: BMC 2008-09-01
Series:Human Genomics
Subjects:
perifosine
cytotoxicity
NCI-60
gene expression
genotype
Online Access:http://www.humgenomics.com/content/3/1/53

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http://www.humgenomics.com/content/3/1/53

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