Epigenetic instability caused by absence of CIZ1 drives transformation during quiescence cycles

Epigenetic instability caused by absence of CIZ1 drives transformation during quiescence cycles

Abstract Background Cip1-interacting zinc finger protein 1 (CIZ1) forms RNA-dependent protein assemblies that stabilise epigenetic state, notable at the inactive X chromosome in females. CIZ1 has been linked with a range of human cancers and in mice genetic deletion of CIZ1 manifests as hyperprolife...

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Bibliographic Details
Main Authors: Olivia G. Dobbs, Rosemary H. C. Wilson, Katherine Newling, Justin F.-X. Ainscough, Dawn Coverley
Format: Article
Language:English
Published: BMC 2023-08-01
Series:BMC Biology
Subjects:
Quiescence
CIZ1
Nuclear condensation
H4K20me1
Epigenetic instability
Online Access:https://doi.org/10.1186/s12915-023-01671-6

Internet

https://doi.org/10.1186/s12915-023-01671-6

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