m6A demethylase ALKBH5 attenuates doxorubicin-induced cardiotoxicity via posttranscriptional stabilization of Rasal3

m6A demethylase ALKBH5 attenuates doxorubicin-induced cardiotoxicity via posttranscriptional stabilization of Rasal3

Summary: The clinical application of anthracyclines such as doxorubicin (DOX) is limited due to their cardiotoxicity. N6-methyladenosine (m6A) plays an essential role in numerous biological processes. However, the roles of m6A and m6A demethylase ALKBH5 in DOX-induced cardiotoxicity (DIC) remain unc...

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Bibliographic Details
Main Authors: Ri-Feng Gao, Kun Yang, Ya-Nan Qu, Xiang Wei, Jia-Ran Shi, Chun-Yu Lv, Yong-Chao Zhao, Xiao-Lei Sun, Ying-Jia Xu, Yi-Qing Yang
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:iScience
Subjects:
Biological sciences
Pathophysiology
Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223002924

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http://www.sciencedirect.com/science/article/pii/S2589004223002924

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