Genomic Amplification of TBC1D31 Promotes Hepatocellular Carcinoma Through Reducing the Rab22A‐Mediated Endolysosomal Trafficking and Degradation of EGFR

Genomic Amplification of TBC1D31 Promotes Hepatocellular Carcinoma Through Reducing the Rab22A‐Mediated Endolysosomal Trafficking and Degradation of EGFR

Abstract Hepatocellular carcinomas (HCCs) are characterized by a vast spectrum of somatic copy number alterations (CNAs); however, their functional relevance is largely unknown. By performing a genome‐wide survey on prognosis‐associated focal CNAs in 814 HCC patients by an integrative computational...

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Bibliographic Details
Main Authors: Pengbo Cao, Hongxia Chen, Ying Zhang, Qi Zhang, Mengting Shi, Huihui Han, Xiaowen Wang, Liang Jin, Bingqian Guo, Rongjiao Hao, Xi Zhao, Yuanfeng Li, Chengming Gao, Xinyi Liu, Yahui Wang, Aiqing Yang, Chenning Yang, Anfeng Si, Hua Li, Qingfeng Song, Fuchu He, Gangqiao Zhou
Format: Article
Language:English
Published: Wiley 2024-10-01
Series:Advanced Science
Subjects:
8q24.13 amplification
epidermal growth factor receptor (EGFR) trafficking
hepatocellular carcinomas (HCCs)
lenvatinib
Rab22A
TBC1D31
Online Access:https://doi.org/10.1002/advs.202405459

Internet

https://doi.org/10.1002/advs.202405459

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