Personalized approach to patients with statin intolerance based on pharmacogenomics (function of OATP1B1 protein)
Statins, HMG CoA reductase inhibitors, are effective at lowering blood cholesterol levels and protecting against cardiovascular incidents. Their uptake into hepatocytes depends on the activity of the SLCO1B1 gene which codes for the OATP1B1 transporter protein. Pharmacogenomic testing provides us in...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Hrvatski liječnički zbor
2023-01-01
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| Series: | Liječnički vjesnik |
| Subjects: | |
| Online Access: | https://hrcak.srce.hr/file/438252 |
| _version_ | 1827281769224732672 |
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| author | Anja Ćuk Doroteja Đekić Dunja Leskovar Livija Šimičević |
| author_facet | Anja Ćuk Doroteja Đekić Dunja Leskovar Livija Šimičević |
| author_sort | Anja Ćuk |
| collection | DOAJ |
| description | Statins, HMG CoA reductase inhibitors, are effective at lowering blood cholesterol levels and protecting against cardiovascular incidents. Their uptake into hepatocytes depends on the activity of the SLCO1B1 gene which codes for the OATP1B1 transporter protein. Pharmacogenomic testing provides us information about the activity level of a certain protein. Lowered activity level of OATP1B1 protein can prolong the bioavailability of some drugs, such as statins. This greater systemic exposure to statins carries a higher risk of intolerance symptoms when compared to normal function of the OATP1B1 protein. |
| first_indexed | 2024-04-24T09:06:47Z |
| format | Article |
| id | doaj.art-0620707612a14ab190bf289e3ea06a3e |
| institution | Directory Open Access Journal |
| issn | 0024-3477 1849-2177 |
| language | English |
| last_indexed | 2024-04-24T09:06:47Z |
| publishDate | 2023-01-01 |
| publisher | Hrvatski liječnički zbor |
| record_format | Article |
| series | Liječnički vjesnik |
| spelling | doaj.art-0620707612a14ab190bf289e3ea06a3e2024-04-15T18:36:40ZengHrvatski liječnički zborLiječnički vjesnik0024-34771849-21772023-01-01145Supp 2777710.26800/LV-145-supl2-CR62Personalized approach to patients with statin intolerance based on pharmacogenomics (function of OATP1B1 protein)Anja Ćuk0Doroteja ĐekićDunja LeskovarLivija ŠimičevićSchool of Medicine, University of Zagreb, Zagreb, CroatiaStatins, HMG CoA reductase inhibitors, are effective at lowering blood cholesterol levels and protecting against cardiovascular incidents. Their uptake into hepatocytes depends on the activity of the SLCO1B1 gene which codes for the OATP1B1 transporter protein. Pharmacogenomic testing provides us information about the activity level of a certain protein. Lowered activity level of OATP1B1 protein can prolong the bioavailability of some drugs, such as statins. This greater systemic exposure to statins carries a higher risk of intolerance symptoms when compared to normal function of the OATP1B1 protein.https://hrcak.srce.hr/file/438252dyslipidemiahmg coa statinsOATP1B1 protein, humanpharmacogenomics |
| spellingShingle | Anja Ćuk Doroteja Đekić Dunja Leskovar Livija Šimičević Personalized approach to patients with statin intolerance based on pharmacogenomics (function of OATP1B1 protein) Liječnički vjesnik dyslipidemia hmg coa statins OATP1B1 protein, human pharmacogenomics |
| title | Personalized approach to patients with statin intolerance based on pharmacogenomics (function of OATP1B1 protein) |
| title_full | Personalized approach to patients with statin intolerance based on pharmacogenomics (function of OATP1B1 protein) |
| title_fullStr | Personalized approach to patients with statin intolerance based on pharmacogenomics (function of OATP1B1 protein) |
| title_full_unstemmed | Personalized approach to patients with statin intolerance based on pharmacogenomics (function of OATP1B1 protein) |
| title_short | Personalized approach to patients with statin intolerance based on pharmacogenomics (function of OATP1B1 protein) |
| title_sort | personalized approach to patients with statin intolerance based on pharmacogenomics function of oatp1b1 protein |
| topic | dyslipidemia hmg coa statins OATP1B1 protein, human pharmacogenomics |
| url | https://hrcak.srce.hr/file/438252 |
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