Pepsin Promotes Activation of Epidermal Growth Factor Receptor and Downstream Oncogenic Pathways, at Slightly Acidic and Neutral pH, in Exposed Hypopharyngeal Cells

Pepsin Promotes Activation of Epidermal Growth Factor Receptor and Downstream Oncogenic Pathways, at Slightly Acidic and Neutral pH, in Exposed Hypopharyngeal Cells

Pepsin refluxate is considered a risk factor for laryngopharyngeal carcinogenesis. Non-acidic pepsin was previously linked to an inflammatory and tumorigenic effect on laryngopharyngeal cells in vitro. Yet there is no clear evidence of the pepsin-effect on a specific oncogenic pathway and the import...

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Bibliographic Details
Main Authors: Panagiotis G. Doukas, Dimitra P. Vageli, Clarence T. Sasaki, Benjamin L. Judson
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
pepsin
EGFR
STAT3
NF-<i>κ</i>B
laryngopharyngeal reflux
non-acidic reflux
Online Access:https://www.mdpi.com/1422-0067/22/8/4275

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https://www.mdpi.com/1422-0067/22/8/4275

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