Rescue of Dopamine Neurons from Iron-Dependent Ferroptosis by Doxycycline and Demeclocycline and Their Non-Antibiotic Derivatives

Rescue of Dopamine Neurons from Iron-Dependent Ferroptosis by Doxycycline and Demeclocycline and Their Non-Antibiotic Derivatives

Several studies have reported that the tetracycline (TC) class antibiotic doxycycline (<b>DOX</b>) is effective against Parkinson’s disease (PD) pathomechanisms. The aim of the present work was three-fold: (i) Establish a model system to better characterize neuroprotection by <b>DO...

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Bibliographic Details
Main Authors: Aurore Tourville, Sarah Viguier, Florencia González-Lizárraga, Rodrigo Hernán Tomas-Grau, Paola Ramirez, Jean-Michel Brunel, Mauricio Dos Santos Pereira, Elaine Del-Bel, Rosana Chehin, Laurent Ferrié, Rita Raisman-Vozari, Bruno Figadère, Patrick Pierre Michel
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Antioxidants
Subjects:
dopamine neurons
ferroptosis
mitochondria
neuroprotection
oxidative stress
Parkinson’s disease
Online Access:https://www.mdpi.com/2076-3921/12/3/575

Internet

https://www.mdpi.com/2076-3921/12/3/575

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