Prevalence and mechanisms of evolutionary contingency in human influenza H3N2 neuraminidase

Prevalence and mechanisms of evolutionary contingency in human influenza H3N2 neuraminidase

Lei et al. systematically characterized the epistasis among natural mutations in the neuraminidase of human influenza H3N2 virus, which provide insights into the biophysical constraints that shaped its evolution trajectory over the past half-century.

Bibliographic Details
Main Authors: Ruipeng Lei, Timothy J. C. Tan, Andrea Hernandez Garcia, Yiquan Wang, Meghan Diefenbacher, Chuyun Teo, Gopika Gopan, Zahra Tavakoli Dargani, Qi Wen Teo, Claire S. Graham, Christopher B. Brooke, Satish K. Nair, Nicholas C. Wu
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-34060-8

Internet

https://doi.org/10.1038/s41467-022-34060-8

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