FOXO1 Couples KGF and PI-3K/AKT Signaling to NKX2.1-Regulated Differentiation of Alveolar Epithelial Cells

FOXO1 Couples KGF and PI-3K/AKT Signaling to NKX2.1-Regulated Differentiation of Alveolar Epithelial Cells

NKX2.1 is a master regulator of lung morphogenesis and cell specification; however, interactions of NKX2.1 with various transcription factors to regulate cell-specific gene expression and cell fate in the distal lung remain incompletely understood. FOXO1 is a key regulator of stem/progenitor cell ma...

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Bibliographic Details
Main Authors: Qian Zhong, Yixin Liu, Michele Ramos Correa, Crystal Nicole Marconett, Parviz Minoo, Changgong Li, David K. Ann, Beiyun Zhou, Zea Borok
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cells
Subjects:
FOXO1-NKX2.1 interaction
keratinocyte growth factor (KGF)
PI-3K/AKT
alveolar epithelial cell
differentiation
transcription
Online Access:https://www.mdpi.com/2073-4409/11/7/1122

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https://www.mdpi.com/2073-4409/11/7/1122

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