Epidermal growth factor treatment of female mice that express APOE4 at an age of advanced pathology mitigates behavioral and cerebrovascular dysfunction

Epidermal growth factor treatment of female mice that express APOE4 at an age of advanced pathology mitigates behavioral and cerebrovascular dysfunction

APOE4 is a major genetic risk factor for Alzheimer's disease and high amyloid-β (Aβ) levels in the brain are a pathological hallmark of the disease. However, the contribution of specific APOE-modulated Aβ-dependent and Aβ-independent functions to cognitive decline remain unclear. Increasing evi...

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Bibliographic Details
Main Authors: Steve Zaldua, Frederick C. Damen, Rohan Pisharody, Riya Thomas, Kelly D. Fan, Giri K. Ekkurthi, Sarah B. Scheinman, Sami Alahmadi, Felecia M. Marottoli, Simon Alford, Kejia Cai, Leon M. Tai
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Heliyon
Subjects:
Biochemistry
Cell biology
Neuroscience
Pathology
Pathophysiology
APOE4
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844020307647

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http://www.sciencedirect.com/science/article/pii/S2405844020307647

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