NFκB and NLRP3/NLRC4 inflammasomes regulate differentiation, activation and functional properties of monocytes in response to distinct SARS-CoV-2 proteins

NFκB and NLRP3/NLRC4 inflammasomes regulate differentiation, activation and functional properties of monocytes in response to distinct SARS-CoV-2 proteins

Abstract Increased recruitment of transitional and non-classical monocytes in the lung during SARS-CoV-2 infection is associated with COVID-19 severity. However, whether specific innate sensors mediate the activation or differentiation of monocytes in response to different SARS-CoV-2 proteins remain...

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Bibliographic Details
Main Authors: Ilya Tsukalov, Ildefonso Sánchez-Cerrillo, Olga Rajas, Elena Avalos, Gorane Iturricastillo, Laura Esparcia, María José Buzón, Meritxell Genescà, Camila Scagnetti, Olga Popova, Noa Martin-Cófreces, Marta Calvet-Mirabent, Ana Marcos-Jimenez, Pedro Martínez-Fleta, Cristina Delgado-Arévalo, Ignacio de los Santos, Cecilia Muñoz-Calleja, María José Calzada, Isidoro González Álvaro, José Palacios-Calvo, Arantzazu Alfranca, Julio Ancochea, Francisco Sánchez-Madrid, Enrique Martin-Gayo
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-46322-8

Internet

https://doi.org/10.1038/s41467-024-46322-8

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