Glutaredoxin-1 alleviates acetaminophen-induced liver injury by decreasing its toxic metabolites

Glutaredoxin-1 alleviates acetaminophen-induced liver injury by decreasing its toxic metabolites

Excessive N-acetyl-p-benzoquinone imine (NAPQI) formation is a starting event that triggers oxidative stress and subsequent hepatocyte necrosis in acetaminophen (APAP) overdose caused acute liver failure (ALF). S-glutathionylation is a reversible redox post-translational modification and a prospecti...

Full description

Bibliographic Details
Main Authors: Ying Xu, Yan Xia, Qinhui Liu, Xiandan Jing, Qin Tang, Jinhang Zhang, Qingyi Jia, Zijing Zhang, Jiahui Li, Jiahao Chen, Yimin Xiong, Yanping Li, Jinhan He
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Journal of Pharmaceutical Analysis
Subjects:
Glutaredoxin-1
S-glutathionylation
Acetaminophen
Toxic metabolites
Cyp3a11
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177923001855

Internet

http://www.sciencedirect.com/science/article/pii/S2095177923001855

Similar Items