Hunting for the cause: Evidence for prion-like mechanisms in Huntington’s disease

The hypothesis that pathogenic protein aggregates associated with neurodegenerative diseases spread from cell-to-cell in the brain in a manner akin to infectious prions has gained substantial momentum due to an explosion of research in the past 10–15 years. Here, we review current evidence supportin...

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Bibliographic Details
Main Authors: Kirby M. Donnelly, Cevannah M. Coleman, Madison L. Fuller, Victoria L. Reed, Dayna Smerina, David S. Tomlinson, Margaret M. Panning Pearce
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.946822/full