Tracking fructose 1,6-bisphosphate dynamics in liver cancer cells using a fluorescent biosensor

Tracking fructose 1,6-bisphosphate dynamics in liver cancer cells using a fluorescent biosensor

Summary: HYlight is a genetically encoded fluorescent biosensor that ratiometrically monitors fructose 1,6-bisphosphate (FBP), a key glycolytic metabolite. Given the role of glucose in liver cancer metabolism, we expressed HYlight in human liver cancer cells and primary mouse hepatocytes. Through in...

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Bibliographic Details
Main Authors: Israel Pérez-Chávez, John N. Koberstein, Julia Malo Pueyo, Eduardo H. Gilglioni, Didier Vertommen, Nicolas Baeyens, Daria Ezeriņa, Esteban N. Gurzov, Joris Messens
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:iScience
Subjects:
biochemistry methods
cancer
metabolomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224025616

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http://www.sciencedirect.com/science/article/pii/S2589004224025616

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