Improved Solubility of Vortioxetine Using C2-C4 Straight-Chain Dicarboxylic Acid Salt Hydrates

Improved Solubility of Vortioxetine Using C2-C4 Straight-Chain Dicarboxylic Acid Salt Hydrates

The purpose of this study was to improve the solubility of vortioxetine by crystal engineering principles. In this paper, three C2-C4 straight-chain dicarboxylic acid salt hydrates of vortioxetine (VOT-OA, VOT-MA-H2O, and VOT-SUA-H2O, VOT = vortioxetine, OA = Oxalic acid, MA = malonic acid, SUA = su...

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Bibliographic Details
Main Authors: Lei Gao, Xian-Rui Zhang, Shao-Ping Yang, Juan-Juan Liu, Chao-Jie Chen
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Crystals
Subjects:
vortioxetine
dicarboxylic acid
salt hydrates
crystal structure
Online Access:http://www.mdpi.com/2073-4352/8/9/352

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http://www.mdpi.com/2073-4352/8/9/352

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