Baicalin attenuates pulmonary vascular remodeling by inhibiting calpain-1 mediated endothelial-to-mesenchymal transition

Baicalin attenuates pulmonary vascular remodeling by inhibiting calpain-1 mediated endothelial-to-mesenchymal transition

Background: Previous studies have demonstrated the beneficial effect of baicalin on pulmonary arterial hypertension (PAH), but the mechanism is unclear. Aim: The aim of the present study was to evaluate the effect of baicalin on pulmonary vascular remodeling (PVR) with a focus on calpain-1-mediated...

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Bibliographic Details
Main Authors: He-xi Jiang, Xiao-di Wang, Hong-xin Wang, Tong Liu
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Heliyon
Subjects:
Baicalin
Pulmonary vascular remodeling
Endothelial-to-mesenchymal transition
Calpain-1
PI3K/Akt
Pulmonary arterial hypertension
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023102842

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http://www.sciencedirect.com/science/article/pii/S2405844023102842

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