Role of intrapancreatic SPINK1/Spink3 expression in the development of pancreatitis

Role of intrapancreatic SPINK1/Spink3 expression in the development of pancreatitis

Studies on hereditary pancreatitis have provided evidence in favor of central role for trypsin activity in the disease. Identification of genetic variants of trypsinogen linked the protease to the onset of pancreatitis, and biochemical characterization proposed an enzymatic gain of function as the i...

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Bibliographic Details
Main Authors: Masaki eOhmuraya, Aki eSugano, Masahiko eHirota, Yutaka eTakaoka, Ken-ichi eYamamura
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-05-01
Series:Frontiers in Physiology
Subjects:
Autophagy
Trypsinogen
Chronic pancreatitis
Hereditary pancreatitis
SPINK1
Spink3
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00126/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00126/full

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