Case study of semaglutide and cardiovascular outcomes: An application of the Causal Roadmap to a hybrid design for augmenting an RCT control arm with real-world data

Case study of semaglutide and cardiovascular outcomes: An application of the Causal Roadmap to a hybrid design for augmenting an RCT control arm with real-world data

Abstract Introduction: Increasing interest in real-world evidence has fueled the development of study designs incorporating real-world data (RWD). Using the Causal Roadmap, we specify three designs to evaluate the difference in risk of major adverse cardiovascular events (MACE) with oral semagluti...

Full description

Bibliographic Details
Main Authors: Lauren E. Dang, Edwin Fong, Jens Magelund Tarp, Kim Katrine Bjerring Clemmensen, Henrik Ravn, Kajsa Kvist, John B. Buse, Mark van der Laan, Maya Petersen
Format: Article
Language:English
Published: Cambridge University Press 2023-01-01
Series:Journal of Clinical and Translational Science
Subjects:
Causal inference
real-world evidence
hybrid study designs
diabetes
cardiovascular outcomes
Online Access:https://www.cambridge.org/core/product/identifier/S2059866123006568/type/journal_article

Internet

https://www.cambridge.org/core/product/identifier/S2059866123006568/type/journal_article

Similar Items