In silico search for modifier genes associated with pancreatic and liver disease in Cystic Fibrosis.

Cystic Fibrosis is the most common lethal autosomal recessive disorder in the white population, affecting among other organs, the lung, the pancreas and the liver. Whereas Cystic Fibrosis is a monogenic disease, many studies reveal a very complex relationship between genotype and clinical phenotype....

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Bibliographic Details
Main Authors: Pascal Trouvé, Emmanuelle Génin, Claude Férec
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5365109?pdf=render