Synthesis of Novel <i>N</i>-Methylmorpholine-Substituted Benzimidazolium Salts as Potential α-Glucosidase Inhibitors

Synthesis of Novel <i>N</i>-Methylmorpholine-Substituted Benzimidazolium Salts as Potential α-Glucosidase Inhibitors

The α-glucosidase enzyme, located in the brush border of the small intestine, is responsible for overall glycemic control in the body. It hydrolyses the 1,4-linkage in the carbohydrates to form blood-absorbable monosaccharides that ultimately increase the blood glucose level. α-Glucosidase inhibitor...

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Bibliographic Details
Main Authors: Imran Ahmad Khan, Furqan Ahmad Saddique, Sana Aslam, Usman Ali Ashfaq, Matloob Ahmad, Sami A. Al-Hussain, Magdi E. A. Zaki
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Molecules
Subjects:
benzimidazole
morpholine
benzimidazolium salts
molecular docking
α-glucosidase inhibition
antidiabetic studies
Online Access:https://www.mdpi.com/1420-3049/27/18/6012

Internet

https://www.mdpi.com/1420-3049/27/18/6012

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