Leptin signaling in the dorsomedial hypothalamus couples breathing and metabolism in obesity

Leptin signaling in the dorsomedial hypothalamus couples breathing and metabolism in obesity

Summary: Mismatch between CO2 production (Vco2) and respiration underlies the pathogenesis of obesity hypoventilation. Leptin-mediated CNS pathways stimulate both metabolism and breathing, but interactions between these functions remain elusive. We hypothesized that LEPRb+ neurons of the dorsomedial...

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Bibliographic Details
Main Authors: Mateus R. Amorim, Xin Wang, O. Aung, Shannon Bevans-Fonti, Frederick Anokye-Danso, Caitlin Ribeiro, Joan Escobar, Carla Freire, Huy Pho, Olga Dergacheva, Luiz G.S. Branco, Rexford S. Ahima, David Mendelowitz, Vsevolod Y. Polotsky
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Cell Reports
Subjects:
CP: Neuroscience
CP: Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723015243

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http://www.sciencedirect.com/science/article/pii/S2211124723015243

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