Synthesis of an Hsp70 inhibitor and its assessment of lysosomal membrane permeabilization

Summary: Hsp70 inhibitors have great potential as chemical probes and anticancer agents. Thus, it is important to elucidate their modes of action on cancer cell death. This protocol describes a step-by-step process for the synthesis of apoptozole as an inhibitor of Hsp70, analysis of internalization...

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Bibliographic Details
Main Authors: Sang-Hyun Park, Sookil Park, Injae Shin
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:STAR Protocols
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2666166721000563