Synthesis of indole-based oxadiazoles and their interaction with bacterial peptidoglycan and SARS-CoV-2 main protease: In vitro, molecular docking and in silico ADME/Tox study

Synthesis of indole-based oxadiazoles and their interaction with bacterial peptidoglycan and SARS-CoV-2 main protease: In vitro, molecular docking and in silico ADME/Tox study

In the present study, Indole-based-oxadiazole (1A-17A) compounds were successfully synthesized. The structures of all synthesized compounds were fully characterized by different sophisticated spectroscopic techniques such 1H NMR, 13C NMR, and HREI-MS. Further, the synthesized compounds were explored...

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Bibliographic Details
Main Authors: Mohammad Azam Ansari, Muhammad Taha, Nizam Uddin, Fazal Rahim, Qazi Mohammad Sajid Jamal, Mohammad N. Alomary, Fahad M. Alshabrmi, Ahmad Almatroudi, Banan Atwah, Zain Alhindi, Naveed Iqbal, Khalid Mohammed Khan
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:Journal of Saudi Chemical Society
Subjects:
Indole
Oxadiazole
Main protease
Peptidoglycan
Multidrug resistant
Antibiofilm
Online Access:http://www.sciencedirect.com/science/article/pii/S1319610322000564

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http://www.sciencedirect.com/science/article/pii/S1319610322000564

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