A Multitrait Locus Regulates Sarbecovirus Pathogenesis

A Multitrait Locus Regulates Sarbecovirus Pathogenesis

ABSTRACT Infectious diseases have shaped the human population genetic structure, and genetic variation influences the susceptibility to many viral diseases. However, a variety of challenges have made the implementation of traditional human Genome-wide Association Studies (GWAS) approaches to study t...

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Bibliographic Details
Main Authors: Alexandra Schäfer, Sarah R. Leist, Lisa E. Gralinski, David R. Martinez, Emma S. Winkler, Kenichi Okuda, Padraig E. Hawkins, Kendra L. Gully, Rachel L. Graham, D. Trevor Scobey, Timothy A. Bell, Pablo Hock, Ginger D. Shaw, Jennifer F. Loome, Emily A. Madden, Elizabeth Anderson, Victoria K. Baxter, Sharon A. Taft-Benz, Mark R. Zweigart, Samantha R. May, Stephanie Dong, Matthew Clark, Darla R. Miller, Rachel M. Lynch, Mark T. Heise, Roland Tisch, Richard C. Boucher, Fernando Pardo Manuel de Villena, Stephanie A. Montgomery, Michael S. Diamond, Martin T. Ferris, Ralph S. Baric
Format: Article
Language:English
Published: American Society for Microbiology 2022-08-01
Series:mBio
Subjects:
collaborative cross
host response
pathogenesis
SARS-CoV-2
sarbecoviruses
Online Access:https://journals.asm.org/doi/10.1128/mbio.01454-22

Internet

https://journals.asm.org/doi/10.1128/mbio.01454-22

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