A cell-based assay for detection of anti-fibrillarin autoantibodies with performance equivalent to immunoprecipitation

A cell-based assay for detection of anti-fibrillarin autoantibodies with performance equivalent to immunoprecipitation

Anti-fibrillarin autoantibodies are useful for the diagnosis and prognosis of systemic sclerosis (SSc). Anti-fibrillarin produces a clumpy nucleolar pattern in indirect immunofluorescence assay on HEp-2 cells (HEp-2 IFA). Here we develop and validate a reliable cell-based anti-fibrillarin assay (Fib...

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Bibliographic Details
Main Authors: Gerson Dierley Keppeke, Minoru Satoh, Cristiane Kayser, Pedro Matos, Tomoko Hasegawa, Shin Tanaka, Larissa Diogenes, Rogerio Quintiliano Amaral, Silvia Helena Rodrigues, Luis Eduardo Coelho Andrade
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
anti-fibrillarin
antinuclear antibodies
autoantibody (ies)
biomarkers
cell-based assay
systemic sclerosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1011110/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1011110/full

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