CD137 Costimulation Enhances the Antitumor Activity of Vγ9Vδ2-T Cells in IL-10-Mediated Immunosuppressive Tumor Microenvironment

CD137 Costimulation Enhances the Antitumor Activity of Vγ9Vδ2-T Cells in IL-10-Mediated Immunosuppressive Tumor Microenvironment

Although γδ-T cell-based tumor immunotherapy using phosphoantigens to boost γδ-T cell immunity has shown success in some cancer patients, the clinical application is limited due to the rapid exhaustion of Vγ9Vδ2-T cells caused by repetitive stimulation from phosphoantigens and the profoundly immunos...

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Bibliographic Details
Main Authors: Yujun Pei, Zheng Xiang, Kun Wen, Chloe Ran Tu, Xiwei Wang, Yanmei Zhang, Xiaofeng Mu, Yinping Liu, Wenwei Tu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
CD137
γδ-T cells
antitumor acitivity
IL-10
immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.872122/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.872122/full

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