A CD64/FcγRI-mediated mechanism hijacks PD-1 from PD-L1/2 interaction and enhances anti-PD-1 functional recovery of exhausted T cells

A CD64/FcγRI-mediated mechanism hijacks PD-1 from PD-L1/2 interaction and enhances anti-PD-1 functional recovery of exhausted T cells

Therapeutic monoclonal antibodies (mAb) targeting the immune checkpoint inhibitor programmed cell death protein 1 (PD-1) have achieved considerable clinical success in anti-cancer therapy through relieving T cell exhaustion. Blockade of PD-1 interaction with its ligands PD-L1 and PD-L2 is an importa...

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Bibliographic Details
Main Authors: Victor Joo, Constantinos Petrovas, Laurence de Leval, Alessandra Noto, Michel Obeid, Craig Fenwick, Giuseppe Pantaleo
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Immunology
Subjects:
PD1 (programmed cell death protein 1)
immunotherapy
internalization
FcγRI(CD64)
T cell
mAb
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1213375/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1213375/full

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