NSP4 and ORF9b of SARS-CoV-2 Induce Pro-Inflammatory Mitochondrial DNA Release in Inner Membrane-Derived Vesicles

NSP4 and ORF9b of SARS-CoV-2 Induce Pro-Inflammatory Mitochondrial DNA Release in Inner Membrane-Derived Vesicles

Circulating cell-free mitochondrial DNA (cf-mtDNA) has been found in the plasma of severely ill COVID-19 patients and is now known as a strong predictor of mortality. However, the underlying mechanism of mtDNA release is unexplored. Here, we show a novel mechanism of SARS-CoV-2-mediated pro-inflamma...

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Bibliographic Details
Main Authors: Md Imam Faizan, Rituparna Chaudhuri, Shakti Sagar, Sarah Albogami, Nisha Chaudhary, Iqbal Azmi, Areej Akhtar, Syed Mansoor Ali, Rohit Kumar, Jawed Iqbal, Mohan C. Joshi, Gaurav Kharya, Pankaj Seth, Soumya Sinha Roy, Tanveer Ahmad
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cells
Subjects:
mitochondrial DNA
SARS-CoV-2
NSP4
ORF9b
myeloid cell leukemia-1
BCL2 antagonist/killer
Online Access:https://www.mdpi.com/2073-4409/11/19/2969

Internet

https://www.mdpi.com/2073-4409/11/19/2969

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