Design, Synthesis, and Investigation of Novel Nitric Oxide (NO)-Releasing Aromatic Aldehydes as Drug Candidates for the Treatment of Sickle Cell Disease

Design, Synthesis, and Investigation of Novel Nitric Oxide (NO)-Releasing Aromatic Aldehydes as Drug Candidates for the Treatment of Sickle Cell Disease

Sickle cell disease (SCD) is caused by a single-point mutation, and the ensuing deoxygenation-induced polymerization of sickle hemoglobin (HbS), and reduction in bioavailability of vascular nitric oxide (NO), contribute to the pathogenesis of the disease. In a proof-of-concept study, we successfully...

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Bibliographic Details
Main Authors: Boshi Huang, Mohini S. Ghatge, Akua K. Donkor, Faik N. Musayev, Tanvi M. Deshpande, Mohammed Al-Awadh, Rana T. Alhashimi, Hongmei Zhu, Abdelsattar M. Omar, Marilyn J. Telen, Yan Zhang, Tim J. McMahon, Osheiza Abdulmalik, Martin K. Safo
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Molecules
Subjects:
hemoglobin
sickle cell disease
antisickling
nitric oxide
oxygen equilibrium curve
antiadhesion
Online Access:https://www.mdpi.com/1420-3049/27/20/6835

Internet

https://www.mdpi.com/1420-3049/27/20/6835

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