Late plasma exosome microRNA-21-5p depicts magnitude of reverse ventricular remodeling after early surgical repair of primary mitral valve regurgitation

Late plasma exosome microRNA-21-5p depicts magnitude of reverse ventricular remodeling after early surgical repair of primary mitral valve regurgitation

IntroductionPrimary mitral valve regurgitation (MR) results from degeneration of mitral valve apparatus. Mechanisms leading to incomplete postoperative left ventricular (LV) reverse remodeling (Rev–Rem) despite timely and successful surgical mitral valve repair (MVR) remain unknown. Plasma exosomes...

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Bibliographic Details
Main Authors: Fausto Pizzino, Giulia Furini, Valentina Casieri, Massimiliano Mariani, Giacomo Bianchi, Simona Storti, Dante Chiappino, Stefano Maffei, Marco Solinas, Giovanni Donato Aquaro, Vincenzo Lionetti
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
exosomes
reverse remodeling
mitral valve (MV) repair
heart surgery
postoperative
miR-21-5p
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.943068/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2022.943068/full

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