Defining the HIV Capsid Binding Site of Nucleoporin 153

Defining the HIV Capsid Binding Site of Nucleoporin 153

ABSTRACT The interaction between the HIV-1 capsid and human nucleoporin 153 (NUP153) is vital for delivering the HIV-1 preintegration complex into the nucleus via the nuclear pore complex. The interaction with the capsid requires a phenylalanine/glycine-containing motif in the C-terminus of NUP153 (...

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Bibliographic Details
Main Authors: Shunji Li, Jagdish Suresh Patel, Jordan Yang, Angela Marie Crabtree, Brenda Marilyn Rubenstein, Peik Karl Lund-Andersen, Frederick Marty Ytreberg, Paul Andrew Rowley
Format: Article
Language:English
Published: American Society for Microbiology 2022-10-01
Series:mSphere
Subjects:
HIV
NUP153
capsid
molecular modeling
FoldX
PyRosetta
Online Access:https://journals.asm.org/doi/10.1128/msphere.00310-22

Internet

https://journals.asm.org/doi/10.1128/msphere.00310-22

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