Identifying chemogenetic interactions from CRISPR screens with drugZ

Identifying chemogenetic interactions from CRISPR screens with drugZ

Abstract Background Chemogenetic profiling enables the identification of gene mutations that enhance or suppress the activity of chemical compounds. This knowledge provides insights into drug mechanism of action, genetic vulnerabilities, and resistance mechanisms, all of which may help stratify pati...

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Bibliographic Details
Main Authors: Medina Colic, Gang Wang, Michal Zimmermann, Keith Mascall, Megan McLaughlin, Lori Bertolet, W. Frank Lenoir, Jason Moffat, Stephane Angers, Daniel Durocher, Traver Hart
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Genome Medicine
Subjects:
CRISPR screens
Chemogenetic interactions
Drug resistance
Synthetic lethality
Online Access:http://link.springer.com/article/10.1186/s13073-019-0665-3

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http://link.springer.com/article/10.1186/s13073-019-0665-3

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