Polysarcosine-Functionalized mRNA Lipid Nanoparticles Tailored for Immunotherapy

Polysarcosine-Functionalized mRNA Lipid Nanoparticles Tailored for Immunotherapy

Lipid nanoparticles (LNPs) have gained great attention as carriers for mRNA-based therapeutics, finding applications in various indications, extending beyond their recent use in vaccines for infectious diseases. However, many aspects of LNP structure and their effects on efficacy are not well charac...

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Bibliographic Details
Main Authors: Christoph Wilhelmy, Isabell Sofia Keil, Lukas Uebbing, Martin A. Schroer, Daniel Franke, Thomas Nawroth, Matthias Barz, Ugur Sahin, Heinrich Haas, Mustafa Diken, Peter Langguth
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Pharmaceutics
Subjects:
lipid nanoparticles
LNPs
mRNA
small-angle X-ray scattering
polysarcosine
flow cytometry
Online Access:https://www.mdpi.com/1999-4923/15/8/2068

Internet

https://www.mdpi.com/1999-4923/15/8/2068

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