Combination of Whole-Brain Radiotherapy with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors Improves Overall Survival in EGFR-Mutated Non-Small Cell Lung Cancer Patients with Brain Metastases

Combination of Whole-Brain Radiotherapy with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors Improves Overall Survival in EGFR-Mutated Non-Small Cell Lung Cancer Patients with Brain Metastases

Brain metastases (BM) cause morbidity and mortality in patients with non-small cell lung cancer (NSCLC). The use of upfront epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) and withholding of whole-brain radiation therapy (WBRT) is controversial. We aim to investigate the im...

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Bibliographic Details
Main Authors: Chien-Hung Chen, Hsin-Hua Lee, Hung-Yi Chuang, Jen-Yu Hung, Ming-Yii Huang, Inn-Wen Chong
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Cancers
Subjects:
brain metastases
epidermal growth factor receptor
non-small cell lung cancer
whole-brain radiotherapy
tyrosine kinase inhibitors
Online Access:https://www.mdpi.com/2072-6694/11/8/1092

Internet

https://www.mdpi.com/2072-6694/11/8/1092

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