Neoadjuvant Intratumoral Immunotherapy with Cowpea Mosaic Virus Induces Local and Systemic Antitumor Efficacy in Canine Mammary Cancer Patients

Neoadjuvant Intratumoral Immunotherapy with Cowpea Mosaic Virus Induces Local and Systemic Antitumor Efficacy in Canine Mammary Cancer Patients

The lack of optimal models to evaluate novel agents is delaying the development of effective immunotherapies against human breast cancer (BC). In this prospective open label study, we applied neoadjuvant intratumoral immunotherapy with empty cowpea mosaic virus-like particles (eCPMV) to 11 companion...

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Bibliographic Details
Main Authors: Guillermo Valdivia, Daniel Alonso-Miguel, Maria Dolores Perez-Alenza, Anna Barbara Emilia Zimmermann, Evelien Schaafsma, Fred W. Kolling, Lucia Barreno, Angela Alonso-Diez, Veronique Beiss, Jessica Fernanda Affonso de Oliveira, María Suárez-Redondo, Steven Fiering, Nicole F. Steinmetz, Johannes vom Berg, Laura Peña, Hugo Arias-Pulido
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Cells
Subjects:
canine mammary cancer
intratumoral immunotherapy
plant virus
cowpea mosaic virus
nanoparticles
immune cells
Online Access:https://www.mdpi.com/2073-4409/12/18/2241

Internet

https://www.mdpi.com/2073-4409/12/18/2241

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