Differential Role of Cathepsins S and B In Hepatic APC-Mediated NKT Cell Activation and Cytokine Secretion

Differential Role of Cathepsins S and B In Hepatic APC-Mediated NKT Cell Activation and Cytokine Secretion

Natural killer T (NKT) cells exhibit a specific tissue distribution, displaying the liver the highest NKT/conventional T cell ratio. Upon antigen stimulation, NKT cells secrete Th1 cytokines, including interferon γ (IFNγ), and Th2 cytokines, including IL-4 that recruit and activate other innate immu...

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Bibliographic Details
Main Authors: Álvaro de Mingo Pulido, Estefanía de Gregorio, Shilpi Chandra, Anna Colell, Albert Morales, Mitchell Kronenberg, Montserrat Marí
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Immunology
Subjects:
iNKT
cathepsins
inflammation
liver damage
NF-κB
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00391/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00391/full

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