Modulation of Malaria Phenotypes by Pyruvate Kinase (PKLR) Variants in a Thai Population.

Modulation of Malaria Phenotypes by Pyruvate Kinase (PKLR) Variants in a Thai Population.

Pyruvate kinase (PKLR) is a critical erythrocyte enzyme that is required for glycolysis and production of ATP. We have shown that Pklr deficiency in mice reduces the severity (reduced parasitemia, increased survival) of blood stage malaria induced by infection with Plasmodium chabaudi AS. Likewise,...

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Библиографические подробности
Главные авторы: Rebekah van Bruggen, Christian Gualtieri, Alexandra Iliescu, Chalisa Louicharoen Cheepsunthorn, Punchalee Mungkalasut, Jean-François Trape, David Modiano, Bienvenu Sodiomon Sirima, Pratap Singhasivanon, Mark Lathrop, Anavaj Sakuntabhai, Jean-François Bureau, Philippe Gros
Формат: Статья
Язык:English
Опубликовано: Public Library of Science (PLoS) 2015-01-01
Серии:PLoS ONE
Online-ссылка:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0144555&type=printable

Internet

https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0144555&type=printable

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