Modeling Late-Onset Sporadic Alzheimer’s Disease through BMI1 Deficiency

Modeling Late-Onset Sporadic Alzheimer’s Disease through BMI1 Deficiency

Late-onset sporadic Alzheimer’s disease (AD) is the most prevalent form of dementia, but its origin remains poorly understood. The Bmi1/Ring1 protein complex maintains transcriptional repression of developmental genes through histone H2A mono-ubiquitination, and Bmi1 deficiency in mice results in gr...

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Bibliographic Details
Main Authors: Anthony Flamier, Jida El Hajjar, James Adjaye, Karl J. Fernandes, Mohamed Abdouh, Gilbert Bernier
Format: Article
Language:English
Published: Elsevier 2018-05-01
Series:Cell Reports
Subjects:
Alzheimer’s disease
dementia
sporadic
BMI1
polycomb
amyloid
Tau
p53
GSK3b
MAPT
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718306752

Internet

http://www.sciencedirect.com/science/article/pii/S2211124718306752

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